25º Congresso Brasileiro de Microbiologia

਀㰀倀㸀㰀匀吀刀伀一䜀㸀䐀䤀䘀䔀刀刀䔀一吀䤀䄀䰀䴀䔀䐀䤀䄀吀䤀伀一伀䘀一䔀唀吀刀伀倀䠀䤀䰀䄀䌀䌀唀䴀唀䰀䄀吀䤀伀一䤀一䐀唀䌀䔀䐀䈀夀㰀⼀匀吀刀伀一䜀㸀㰀匀吀刀伀一䜀㸀䈀䌀䜀䤀一䴀伀唀匀䔀倀䰀䔀唀刀䤀匀夀㰀⼀匀吀刀伀一䜀㸀㰀⼀倀㸀㰀⼀䘀伀一吀㸀㰀⼀䘀伀一吀㸀㰀⼀䐀䤀嘀㸀㰀⼀猀琀爀漀渀最㸀㰀⼀瀀㸀㰀瀀愀氀椀最渀㴀樀甀猀琀椀昀礀㸀㰀戀㸀䄀渀搀爀攀䰀甀椀猀倀攀椀砀漀琀漀䌀愀渀搀愀㰀⼀戀㸀 ⠀㰀椀㸀䘀椀漀挀爀甀稀㰀⼀椀㸀⤀㬀㰀戀㸀伀挀琀瘀椀漀䴀攀渀攀稀攀猀搀攀䰀椀洀愀䨀爀㰀⼀戀㸀 ⠀㰀椀㸀䘀椀漀挀爀甀稀㰀⼀椀㸀⤀㬀㰀戀㸀䔀氀愀椀渀攀䌀爀甀稀刀漀猀愀猀㰀⼀戀㸀 ⠀㰀椀㸀䘀椀漀挀爀甀稀㰀⼀椀㸀⤀㬀㰀戀㸀䴀愀爀椀愀搀愀猀䜀爀愀愀猀䴀甀氀氀攀爀搀攀伀氀椀瘀攀椀爀愀䠀攀渀爀椀焀甀攀猀㰀⼀戀㸀 ⠀㰀椀㸀䘀椀漀挀爀甀稀㰀⼀椀㸀⤀㰀戀爀㸀㰀戀爀㸀㰀⼀瀀㸀㰀戀㸀㰀昀漀渀琀猀椀稀攀㴀㈀㸀刀攀猀甀洀漀㰀⼀昀漀渀琀㸀㰀⼀戀㸀㰀瀀愀氀椀最渀㴀樀甀猀琀椀昀礀挀氀愀猀猀㴀琀爀攀猀㸀㰀昀漀渀琀猀椀稀攀㴀㈀㸀㰀䘀伀一吀昀愀挀攀㴀嘀攀爀搀愀渀愀猀椀稀攀㴀㈀㸀☀渀戀猀瀀㬀㰀⼀䘀伀一吀㸀
Introduction: Mycobacterial infections are among the main health problems worldwide. However, the initial inflammatory events during pulmonary mycobacterial infection are still unclear. There are increasing evidences that neutrophils are important in the control of mycobacterial infections, but few studies focused on the investigation of the inflammatory mediators and cytokines involved in mycobacteria-induced neutrophilia. In the present study we performed a pharmacological characterization of several mediators on the leukocyte influx in a murine model of Mycobacterium Bovis-BCG-induced pleurisy, analyzing three different time points of the reaction.
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Conclusion: Our data indicate that BCG-induced neutrophil accumulation is differentially mediated along the several phases of the inflammatory reaction.

Palavras-chave: Micobacterium bovis, tuberculose, bcg, inflamação, neutrófilos