| Área: Imunologia Clínica e Diagnóstico ( Divisão F ) AVALIAÇÃO DA RESPOSTA IMUNITÁRIA CELULAR A ANTÍGENOS MICOBACTERIANOS NO SANGUE PERIFÉRICO DE PACIENTES TUBERCULOSOS E CONTATOS SAUDÁVEIS. Fernanda Luiza Pedrosa Guimarães (IOC/Fiocruz); Vinicius Ribeiro Cabral (IOC/Fiocruz); Else Bartholdy Gribel (ENSP/Fiocruz); Maria Helena Feres Saad (IOC/Fiocruz)
Resumo㰀倀 挀氀愀猀猀㴀䴀猀漀一漀爀洀愀氀 猀琀礀氀攀㴀∀䴀䄀刀䜀䤀一㨀 挀洀 挀洀 瀀琀㬀 䰀䤀一䔀ⴀ䠀䔀䤀䜀䠀吀㨀 㔀 ─㬀 吀䔀堀吀ⴀ䄀䰀䤀䜀一㨀 樀甀猀琀椀昀礀∀㸀䄀 琀甀戀攀爀挀甀氀漀猀攀 ⠀吀䈀⤀ 甀洀愀 搀漀攀渀愀 椀渀昀攀挀琀漀ⴀ挀漀渀琀愀最椀漀猀愀 搀攀 琀爀愀渀猀洀椀猀猀漀 愀爀攀愀⸀ 䄀瀀爀漀砀椀洀愀搀愀洀攀渀琀攀 㤀 ─ 搀漀猀 椀渀搀椀瘀搀甀漀猀 椀渀昀攀挀琀愀搀漀猀 瀀攀爀洀愀渀攀挀攀洀 挀漀洀 愀 椀渀昀攀挀漀 攀洀 攀猀琀愀搀漀 氀愀琀攀渀琀攀 ⠀䰀吀䈀䤀⤀Ⰰ 瀀漀搀攀渀搀漀 瀀漀琀攀渀挀椀愀氀洀攀渀琀攀 搀攀猀攀渀瘀漀氀瘀攀爀 愀 搀漀攀渀愀 愀漀 氀漀渀最漀 搀愀 瘀椀搀愀⸀ 䔀猀琀爀愀琀最椀愀猀 焀甀攀 瀀漀猀猀愀洀 瀀爀攀搀椀稀攀爀 焀甀愀椀猀 搀漀猀 椀渀昀攀挀琀愀搀漀猀 攀猀琀漀 攀洀 爀椀猀挀漀 搀攀 搀攀猀攀渀瘀漀氀瘀攀爀 搀漀攀渀愀 猀攀爀椀愀 搀攀 最爀愀渀搀攀 甀琀椀氀椀搀愀搀攀 渀漀 挀漀渀琀爀漀氀攀 搀愀 吀䈀⸀ 一攀猀琀攀 攀猀琀甀搀漀Ⰰ 漀猀 愀渀琀最攀渀漀猀 㘀欀䐀愀Ⰰ 焀甀攀 洀愀椀猀 瀀爀漀搀甀稀椀搀漀 瀀攀氀愀猀 戀愀挀琀爀椀愀猀 渀漀 椀渀挀椀漀 搀愀 椀渀昀攀挀漀 漀甀 攀洀 猀椀琀甀愀漀 搀攀 㰀䤀 猀琀礀氀攀㴀∀洀猀漀ⴀ戀椀搀椀ⴀ昀漀渀琀ⴀ猀琀礀氀攀㨀 渀漀爀洀愀氀∀㸀猀琀爀攀猀猀㰀⼀䤀㸀Ⰰ 挀漀洀漀 瀀漀爀 攀砀攀洀瀀氀漀 攀洀 攀猀琀愀搀漀 搀攀 氀愀琀渀挀椀愀Ⰰ 攀 愀猀 挀漀洀戀椀渀愀攀猀 ㌀㠀欀䐀愀⼀䌀䘀倀ⴀ 攀 愀 椀渀琀攀爀渀愀挀椀漀渀愀氀洀攀渀琀攀 甀琀椀氀椀稀愀搀愀 䔀匀䄀吀ⴀ㘀⼀䌀䘀倀ⴀ 猀攀爀漀 愀瘀愀氀椀愀搀漀猀Ⰰ 攀洀 瀀愀挀椀攀渀琀攀猀 挀漀洀 吀䈀 瀀甀氀洀漀渀愀爀 攀 猀攀甀猀 挀漀渀琀愀琀漀猀 爀攀挀攀渀琀攀猀 ⠀㰀䤀 猀琀礀氀攀㴀∀洀猀漀ⴀ戀椀搀椀ⴀ昀漀渀琀ⴀ猀琀礀氀攀㨀 渀漀爀洀愀氀∀㸀䌀琀爀㰀⼀䤀㸀⤀ 攀 椀渀搀椀瘀搀甀漀猀 猀愀搀椀漀猀 搀攀 爀攀愀 攀渀搀洀椀挀愀 ⠀㰀䤀 猀琀礀氀攀㴀∀洀猀漀ⴀ戀椀搀椀ⴀ昀漀渀琀ⴀ猀琀礀氀攀㨀 渀漀爀洀愀氀∀㸀䌀愀攀㰀⼀䤀㸀⤀Ⰰ 焀甀愀渀琀漀 愀漀 瀀攀爀昀椀氀 搀攀 爀攀猀瀀漀猀琀愀 瀀漀爀 䤀䘀一ⴀ☀⌀㤀㐀㜀㬀 最攀爀愀搀漀 攀洀 挀愀搀愀 最爀甀瀀漀 搀攀 椀渀搀椀瘀搀甀漀猀⸀ 䌀氀甀氀愀猀 瀀漀氀椀洀漀爀昀漀渀甀挀氀攀愀搀愀猀 搀漀 猀愀渀最甀攀 瀀攀爀椀昀爀椀挀漀 昀漀爀愀洀 漀戀琀椀搀愀猀Ⰰ 攀猀琀椀洀甀氀愀搀愀猀 挀漀洀 漀猀 愀渀琀最攀渀漀猀 瀀爀漀瀀漀猀琀漀猀 攀 漀 䤀䘀一ⴀ㰀匀倀䄀一 猀琀礀氀攀㴀∀䘀伀一吀ⴀ䘀䄀䴀䤀䰀夀㨀 匀礀洀戀漀氀㬀 洀猀漀ⴀ愀猀挀椀椀ⴀ昀漀渀琀ⴀ昀愀洀椀氀礀㨀 ✀吀椀洀攀猀 一攀眀 刀漀洀愀渀✀㬀 洀猀漀ⴀ栀愀渀猀椀ⴀ昀漀渀琀ⴀ昀愀洀椀氀礀㨀 ✀吀椀洀攀猀 一攀眀 刀漀洀愀渀✀㬀 洀猀漀ⴀ挀栀愀爀ⴀ琀礀瀀攀㨀 猀礀洀戀漀氀㬀 洀猀漀ⴀ猀礀洀戀漀氀ⴀ昀漀渀琀ⴀ昀愀洀椀氀礀㨀 匀礀洀戀漀氀∀㸀㰀匀倀䄀一 猀琀礀氀攀㴀∀洀猀漀ⴀ挀栀愀爀ⴀ琀礀瀀攀㨀 猀礀洀戀漀氀㬀 洀猀漀ⴀ猀礀洀戀漀氀ⴀ昀漀渀琀ⴀ昀愀洀椀氀礀㨀 匀礀洀戀漀氀∀㸀最㰀⼀匀倀䄀一㸀㰀⼀匀倀䄀一㸀 瀀爀漀搀甀稀椀搀漀 昀漀椀 洀攀渀猀甀爀愀搀漀 渀漀 猀漀戀爀攀渀愀搀愀渀琀攀 搀愀猀 挀甀氀琀甀爀愀猀 搀攀 氀椀渀昀挀椀琀漀猀 瀀漀爀 洀琀漀搀漀 椀洀甀渀漀攀渀稀椀洀琀椀挀漀 ⠀䔀䰀䤀匀䄀⤀⸀ 䈀愀猀椀挀愀洀攀渀琀攀Ⰰ 昀漀爀愀洀 漀戀琀椀搀漀猀 琀爀猀 琀椀瀀漀猀 搀攀 瀀攀爀昀椀猀 搀攀 爀攀猀瀀漀猀琀愀⸀ 㰀䈀 猀琀礀氀攀㴀∀洀猀漀ⴀ戀椀搀椀ⴀ昀漀渀琀ⴀ眀攀椀最栀琀㨀 渀漀爀洀愀氀∀㸀倀攀爀昀椀氀 㰀⼀䈀㸀 漀戀猀攀爀瘀愀ⴀ猀攀 爀攀猀瀀漀猀琀愀 氀椀渀攀愀爀 漀甀 猀椀洀椀氀愀爀 瀀愀爀愀 漀猀 琀爀猀 愀渀琀最攀渀漀猀⸀ 㰀䈀 猀琀礀氀攀㴀∀洀猀漀ⴀ戀椀搀椀ⴀ昀漀渀琀ⴀ眀攀椀最栀琀㨀 渀漀爀洀愀氀∀㸀倀攀爀昀椀氀 ㈀㰀⼀䈀㸀Ⰰ 攀洀戀漀爀愀 爀攀猀瀀漀渀搀攀渀搀漀 愀漀 㘀欀䐀愀 攀 ㌀㠀欀䐀愀⼀䌀䘀倀ⴀ㰀㼀砀洀氀㨀渀愀洀攀猀瀀愀挀攀 瀀爀攀昀椀砀 㴀 猀琀 渀猀 㴀 ∀甀爀渀㨀猀挀栀攀洀愀猀ⴀ洀椀挀爀漀猀漀昀琀ⴀ挀漀洀㨀漀昀昀椀挀攀㨀猀洀愀爀琀琀愀最猀∀ ⼀㸀㰀猀琀㨀洀攀琀爀椀挀挀漀渀瘀攀爀琀攀爀 眀㨀猀琀㴀∀漀渀∀ 倀爀漀搀甀挀琀䤀䐀㴀∀ Ⰰ 愀∀㸀 Ⰰ 愀㰀⼀猀琀㨀洀攀琀爀椀挀挀漀渀瘀攀爀琀攀爀㸀 爀攀猀瀀漀猀琀愀 洀愀椀猀 攀砀瀀爀攀猀猀椀瘀愀 攀猀琀 搀椀爀攀挀椀漀渀愀搀愀 愀漀 䔀匀䄀吀ⴀ㘀⼀䌀䘀倀ⴀ ⸀ 㰀䈀 猀琀礀氀攀㴀∀洀猀漀ⴀ戀椀搀椀ⴀ昀漀渀琀ⴀ眀攀椀最栀琀㨀 渀漀爀洀愀氀∀㸀倀攀爀昀椀氀 ㌀㰀⼀䈀㸀 栀 洀愀椀漀爀 爀攀猀瀀漀猀琀愀 瀀愀爀愀 漀 㘀欀䐀愀Ⰰ 搀攀挀愀椀渀搀漀 攀洀 搀椀爀攀漀 愀漀 ㌀㠀欀䐀愀⼀䌀䘀倀ⴀ 攀 䔀匀䄀吀ⴀ㘀⼀䌀䘀倀ⴀ ⸀ 䌀漀渀猀椀搀攀爀愀渀搀漀 愀猀 挀愀爀愀挀琀攀爀猀琀椀挀愀猀 搀漀猀 愀渀琀最攀渀漀猀Ⰰ 漀 瀀攀爀昀椀氀 ㌀㰀䈀 猀琀礀氀攀㴀∀洀猀漀ⴀ戀椀搀椀ⴀ昀漀渀琀ⴀ眀攀椀最栀琀㨀 渀漀爀洀愀氀∀㸀 㰀⼀䈀㸀搀攀 爀攀猀瀀漀猀琀愀 瀀漀搀攀爀椀愀 攀猀琀愀爀 爀攀氀愀挀椀漀渀愀搀漀 椀渀昀攀挀漀 氀愀琀攀渀琀攀Ⰰ 攀 愀 爀攀猀瀀漀猀琀愀 愀氀琀愀 愀漀 㘀欀䐀愀 猀攀爀椀愀 瀀爀漀琀攀琀漀爀愀 渀漀 搀攀猀攀渀瘀漀氀瘀椀洀攀渀琀漀 搀愀 吀䈀⸀ 伀 瀀攀爀昀椀氀 ㈀ 搀攀 爀攀猀瀀漀猀琀愀 瀀漀搀攀爀椀愀 攀猀琀愀爀 愀猀猀漀挀椀愀搀漀 挀氀甀氀愀 搀攀 洀攀洀爀椀愀Ⰰ 瀀漀椀猀 搀漀椀猀 㰀䤀 猀琀礀氀攀㴀∀洀猀漀ⴀ戀椀搀椀ⴀ昀漀渀琀ⴀ猀琀礀氀攀㨀 渀漀爀洀愀氀∀㸀䌀琀爀㰀⼀䤀㸀 猀漀 洀漀爀愀搀漀爀攀猀 搀攀 昀愀瘀攀氀愀 挀漀洀 愀氀琀愀 攀渀搀攀洀椀愀 瀀愀爀愀 吀䈀Ⰰ 攀 甀洀 爀攀瘀攀爀琀攀甀 愀 瀀漀猀椀琀椀瘀椀搀愀搀攀 搀漀 倀倀䐀 ⠀渀攀最愀琀椀瘀漀甀⤀⸀ 伀 瀀攀爀昀椀氀 搀攀 爀攀猀瀀漀猀琀愀 瀀漀搀攀 猀攀爀 琀爀愀搀甀稀椀搀漀 攀洀 攀猀琀愀搀漀 搀攀 椀渀昀攀挀漀 爀攀挀攀渀琀攀⸀ 䔀猀琀攀 攀猀琀甀搀漀 洀漀猀琀爀愀 焀甀攀 漀 瀀愀搀爀漀 搀攀 爀攀猀瀀漀猀琀愀 搀攀 䤀䘀一ⴀ☀⌀㤀㐀㜀㬀 猀 挀漀洀戀椀渀愀攀猀 愀猀猀漀挀椀愀搀愀猀 愀漀 㘀欀䐀愀 猀漀 猀椀洀椀氀愀爀攀猀Ⰰ 猀甀最攀爀椀渀搀漀 漀 瀀漀琀攀渀挀椀愀氀 搀攀 愀洀戀愀猀 挀漀洀漀 昀攀爀爀愀洀攀渀琀愀 瀀愀爀愀 愀甀砀椀氀椀愀爀 渀愀 椀搀攀渀琀椀昀椀挀愀漀 搀攀 瀀攀爀昀椀猀 搀攀 爀攀猀瀀漀猀琀愀 瀀漀爀㰀匀倀䄀一 猀琀礀氀攀㴀∀洀猀漀ⴀ猀瀀愀挀攀爀甀渀㨀 礀攀猀∀㸀☀渀戀猀瀀㬀 㰀⼀匀倀䄀一㸀䤀䘀一ⴀ☀⌀㤀㐀㜀㬀 㰀猀琀㨀倀攀爀猀漀渀一愀洀攀 眀㨀猀琀㴀∀漀渀∀ 倀爀漀搀甀挀琀䤀䐀㴀∀攀洀 挀漀渀琀愀琀漀猀⸀ 䔀渀琀爀攀琀愀渀琀漀∀㸀攀洀 挀漀渀琀愀琀漀猀⸀ 䔀渀琀爀攀琀愀渀琀漀㰀⼀猀琀㨀倀攀爀猀漀渀一愀洀攀㸀Ⰰ 瀀愀爀愀 愀猀猀漀挀椀愀爀 愀氀最甀洀 搀攀猀琀攀猀 瀀攀爀昀椀猀 愀漀 爀椀猀挀漀 搀攀 搀攀猀攀渀瘀漀氀瘀攀爀 搀漀攀渀愀 渀攀挀攀猀猀爀椀漀 甀洀 攀猀琀甀搀漀 氀漀渀最椀琀甀搀椀渀愀氀 愀挀漀洀瀀愀渀栀愀渀搀漀ⴀ漀猀 瀀漀爀 瀀攀氀漀 洀攀渀漀猀 搀漀椀猀 愀渀漀猀⸀㰀⼀倀㸀
㰀倀 挀氀愀猀猀㴀䴀猀漀一漀爀洀愀氀 猀琀礀氀攀㴀∀䴀䄀刀䜀䤀一㨀 挀洀 挀洀 瀀琀㬀 䰀䤀一䔀ⴀ䠀䔀䤀䜀䠀吀㨀 㔀 ─㬀 吀䔀堀吀ⴀ䄀䰀䤀䜀一㨀 樀甀猀琀椀昀礀∀㸀匀甀瀀漀爀琀攀 䘀椀渀愀渀挀攀椀爀漀㨀 䌀一倀焀⼀䘀䄀倀䔀刀䨀⼀倀伀䴀ⴀ䘀䤀伀䌀刀唀娀Ⰰ 倀爀漀最爀愀洀愀 搀攀 䌀漀漀瀀攀爀愀漀 䈀爀愀猀椀氀 砀 䄀氀攀洀愀渀栀愀⸀㰀⼀倀㸀㰀⼀匀倀䄀一㸀㰀⼀昀漀渀琀㸀㰀⼀瀀㸀㰀戀爀㸀㰀戀㸀倀愀氀愀瘀爀愀猀ⴀ挀栀愀瘀攀㨀 㰀⼀戀㸀☀渀戀猀瀀㬀䴀礀挀漀戀愀挀琀攀爀椀甀洀 琀甀戀攀爀挀甀氀漀猀椀猀Ⰰ 愀渀琀最攀渀漀猀 爀攀挀漀洀戀椀渀愀渀琀攀猀Ⰰ 椀渀琀攀爀昀攀爀漀渀ⴀ最愀洀愀㰀⼀琀搀㸀㰀⼀琀爀㸀㰀⼀琀愀戀氀攀㸀㰀⼀琀爀㸀㰀⼀琀搀㸀㰀⼀琀愀戀氀攀㸀㰀⼀戀漀搀礀㸀㰀⼀栀琀洀氀㸀
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