<HTML><HEAD><TITLE>25º Congresso Brasileiro de Microbiologia </TITLE><link rel=STYLESHEET type=text/css href=css.css></HEAD><BODY aLink=#ff0000 bgColor=#FFFFFF leftMargin=0 link=#000000 text=#000000 topMargin=0 vLink=#000000 marginheight=0 marginwidth=0><table align=center width=700 cellpadding=0 cellspacing=0><tr><td align=left bgcolor=#cccccc valign=top width=550><font face=arial size=2><strong><font face=Verdana, Arial, Helvetica, sans-serif size=3><font size=1>25º Congresso Brasileiro de Microbiologia </font></font></strong><font face=Verdana size=1><b><br></b></font><font face=Verdana, Arial,Helvetica, sans-serif size=1><strong> </strong></font></font></td><td align=right bgcolor=#cccccc valign=top width=150><font face=arial size=2><strong><font face=Verdana, Arial, Helvetica, sans-serif size=1><font  size=1>ResumoID:1292-2</font></em></font></strong></font></td></tr><tr><td colspan=2><br><br><table align=center width=700><tr><td>Área: <b>Imunologia ( Divisão E )</b><p align=justify><strong><SPAN STYLE="FONT-FAMILY: ARIAL,HELVETICA,SANS-SERIF;"></SPAN><P>DIPHTHERIA ANTITOXIN IGG LEVELS IN MILITARY AND CIVIL BLOOD DONORS FROM RIO DE JANEIRO, BRAZIL<BR></P>਀ 
</strong></p><p align=justify><b>Francisco Almeida Braga Speranza </b>  (<i>UERJ</i>); <b><u>Louisy  Sanches dos Santos </u></b>  (<i>UERJ</i>); <b>Solange  Kiyoko Ishii </b>  (<i>MEX</i>); <b>Raphael  Hirata Junior </b>  (<i>UERJ</i>); <b>Ana  Luiza de Mattos-guaraldi </b>  (<i>UERJ</i>); <b>Lucimar  Gonçalves Milagres </b>  (<i>UERJ</i>)<br><br></p><b><font size=2>Resumo</font></b><p align=justify class=tres><font size=2><div style="text-align: justify;"><span style="font-family: Arial,Helvetica,sans-serif;">Diphtheria is a</span><span style="font-family: &quot;Arial&quot;,&quot;sans-serif&quot;;" lang="EN-US"> life-threatening਀搀椀猀攀愀猀攀 琀栀愀琀 挀愀渀 戀攀 瀀爀攀瘀攀渀琀攀搀 琀栀爀漀甀最栀 椀洀洀甀渀椀稀愀琀椀漀渀⸀ 吀栀攀 爀攀挀漀洀洀攀渀搀攀搀 瘀愀挀挀椀渀愀琀椀漀渀 
schedule in Brazil consists of three doses of diphtheria-tetanus-pertussis਀瘀愀挀挀椀渀攀 ⠀䐀吀倀⤀ 椀渀 琀栀攀 昀椀爀猀琀 礀攀愀爀 漀昀 氀椀昀攀Ⰰ 昀漀氀氀漀眀攀搀 戀礀 愀 戀漀漀猀琀攀爀 搀漀猀攀 愀琀 㔀ⴀ㘀 
years of age. In 2002, the Public Health Agency of Rio de Janeiro (SES-RJ 2002)਀猀琀愀琀攀搀 愀 猀栀椀昀琀椀渀最 椀渀 琀栀攀 愀最攀 搀椀猀琀爀椀戀甀琀椀漀渀 漀昀 挀愀猀攀猀 漀昀 搀椀瀀栀琀栀攀爀椀愀 琀漀 瀀攀爀猀漀渀猀 
over 15 years of age. Current information also indicated the circulation of <i>Corynebacterium਀搀椀瀀栀琀栀攀爀椀愀攀㰀⼀椀㸀 椀渀 漀甀爀 瀀漀瀀甀氀愀琀椀漀渀Ⰰ 椀渀挀氀甀搀椀渀最 挀愀渀挀攀爀 瀀愀琀椀攀渀琀猀 愀渀搀 栀攀愀氀琀栀礀 
vaccinated adults. In response to the huge epidemic that hit the countries of਀琀栀攀 刀甀猀猀椀愀渀 挀漀渀昀攀搀攀爀愀琀椀漀渀Ⰰ 猀椀渀挀攀 ㈀　　㐀 琀栀攀 䈀爀愀稀椀氀椀愀渀 䴀椀渀椀猀琀爀礀 漀昀 䠀攀愀氀琀栀 
recommended an additional diphtheria-tetanus booster dose to be provided every਀猀甀戀猀攀焀甀攀渀琀 ㄀　 礀攀愀爀猀⸀ 匀攀爀漀氀漀最椀挀 搀愀琀愀 漀渀 搀椀猀攀愀猀攀猀 琀栀愀琀 愀爀攀 瀀爀攀瘀攀渀琀愀戀氀攀 戀礀 瘀愀挀挀椀渀攀 
are useful to evaluate the success of immunization programs and to identify਀猀甀猀挀攀瀀琀椀戀氀攀 猀甀戀最爀漀甀瀀猀⸀ 䠀漀眀攀瘀攀爀Ⰰ 琀栀攀爀攀 愀爀攀 㰀攀洀㸀㰀猀瀀愀渀 猀琀礀氀攀㴀∀昀漀渀琀ⴀ眀攀椀最栀琀㨀 渀漀爀洀愀氀㬀∀㸀昀攀眀㰀⼀猀瀀愀渀㸀㰀⼀攀洀㸀 瀀甀戀氀椀猀栀攀搀 搀愀琀愀 爀攀最愀爀搀椀渀最 爀攀最甀氀愀爀 
immunization coverage and immunity of Brazilian adult population. A previous survey਀挀愀爀爀椀攀搀 漀甀琀 漀渀 猀攀爀甀洀 猀愀洀瀀氀攀猀 挀漀氀氀攀挀琀攀搀 昀爀漀洀 戀氀漀漀搀 搀漀渀漀爀猀 漀昀 愀 甀渀椀瘀攀爀猀椀琀愀爀礀 
hospital of Rio de Janeiro from July to October 2002 showed that a high਀瀀爀漀瀀漀爀琀椀漀渀 ⠀縀㜀　─⤀ 漀昀 椀渀搀椀瘀椀搀甀愀氀猀 昀爀漀洀 ㄀㠀 琀漀 ㌀　 礀攀愀爀猀 漀昀 愀最攀 栀愀搀 渀漀渀ⴀ瀀爀漀琀攀挀琀椀瘀攀 
antibody levels against the diphtheria toxin. Considering the potential risk of਀氀漀眀 愀渀琀椀戀漀搀礀 氀攀瘀攀氀猀Ⰰ 琀栀攀猀攀 搀愀琀愀 栀椀最栀氀椀最栀琀 琀栀攀 渀攀攀搀 昀漀爀 愀搀搀椀琀椀漀渀愀氀 
seroepidemiological surveys in <st1:country-region w:st="on"><st1:place w:st="on">Brazil</st1:place></st1:country-region>.<span style="">&nbsp; </span>Due to the possibility of outbreaks of਀爀攀猀瀀椀爀愀琀漀爀礀 搀椀瀀栀琀栀攀爀椀愀 愀洀漀渀最 洀椀氀椀琀愀爀礀Ⰰ 猀攀瘀攀爀愀氀 猀琀甀搀椀攀猀 栀愀瘀攀 戀攀攀渀 瀀攀爀昀漀爀洀攀搀 椀渀 
order to assess the immune status against diphtheria of soldiers in different਀挀漀甀渀琀爀椀攀猀⸀㰀猀瀀愀渀 猀琀礀氀攀㴀∀挀漀氀漀爀㨀 爀攀搀㬀∀㸀㰀猀瀀愀渀 猀琀礀氀攀㴀∀∀㸀☀渀戀猀瀀㬀 㰀⼀猀瀀愀渀㸀㰀⼀猀瀀愀渀㸀䤀渀 
Brazil, little is known about antibody levels against the diphtheria toxin in਀椀渀搀椀瘀椀搀甀愀氀猀 樀漀椀渀椀渀最 洀椀氀椀琀愀爀礀 猀攀爀瘀椀挀攀⸀㰀猀瀀愀渀 猀琀礀氀攀㴀∀∀㸀☀渀戀猀瀀㬀 㰀⼀猀瀀愀渀㸀䤀渀 
this report we determined serum IgG levels to diphtheria toxin of military and਀挀椀瘀椀氀 戀氀漀漀搀 搀漀渀漀爀猀Ⰰ 㰀猀瀀愀渀 猀琀礀氀攀㴀∀∀㸀愀最攀搀 ㄀㠀ⴀ㘀㐀 礀攀愀爀猀Ⰰ 㰀⼀猀瀀愀渀㸀昀爀漀洀 
the Brazilian Army Biology Institute, <st1:place w:st="on"><st1:city w:st="on">Rio਀  搀攀 䨀愀渀攀椀爀漀㰀⼀猀琀㄀㨀挀椀琀礀㸀㰀⼀猀琀㄀㨀瀀氀愀挀攀㸀Ⰰ 甀猀椀渀最 愀 挀漀洀洀攀爀挀椀愀氀 搀椀瀀栀琀栀攀爀椀愀ⴀ䔀䰀䤀匀䄀 欀椀琀⸀ 䴀漀猀琀 
(63.6%) unprotected militaries were from the older age group; 33 to 64 years.਀䤀渀 挀漀渀琀爀愀猀琀Ⰰ 琀栀攀 洀愀樀漀爀椀琀礀 ⠀㜀㈀─⤀ 漀昀 礀漀甀渀最 洀椀氀椀琀愀爀椀攀猀 ⠀㄀㠀 琀漀 ㌀㈀ 礀攀愀爀猀⤀ 眀攀爀攀 昀甀氀氀礀 
protected. Concerning to the civilians, 50% of persons from 18 to 32 years had਀瀀爀漀琀攀挀琀椀瘀攀 愀渀琀椀戀漀搀礀 氀攀瘀攀氀猀 琀漀 搀椀瀀栀琀栀攀爀椀愀 愀猀 眀攀氀氀 㔀㈀─ 漀昀 椀渀搀椀瘀椀搀甀愀氀猀 愀最攀搀 ㌀㌀ 琀漀 
64 years. Civilians had similar antibody response (mean of 0.66 IU/ml)਀椀渀搀攀瀀攀渀搀攀渀琀 漀昀 琀栀攀 愀最攀 最爀漀甀瀀⸀ 䴀椀氀椀琀愀爀椀攀猀 漀昀 ㄀㠀ⴀ㌀㈀ 礀攀愀爀猀 栀愀搀 栀椀最栀 䤀最䜀 氀攀瘀攀氀猀 ⠀洀攀愀渀 
of 0.87 IU/ml) than militaries of 33-64 years (mean of 0.59 IU/ml) (P = 0.03). <span style="">Concluding, t</span></span><span style="font-family: &quot;Arial&quot;,&quot;sans-serif&quot;;" lang="EN-US">he existence of susceptible military and civilian adults creates an਀攀瀀椀搀攀洀椀挀 瀀漀琀攀渀琀椀愀氀 椀渀 漀甀爀 挀漀洀洀甀渀椀琀礀 愀渀搀 爀攀椀渀昀漀爀挀攀猀㰀⼀猀瀀愀渀㸀㰀猀瀀愀渀 猀琀礀氀攀㴀∀昀漀渀琀ⴀ昀愀洀椀氀礀㨀 ☀焀甀漀琀㬀䄀爀椀愀氀☀焀甀漀琀㬀Ⰰ☀焀甀漀琀㬀猀愀渀猀ⴀ猀攀爀椀昀☀焀甀漀琀㬀㬀∀ 氀愀渀最㴀∀䔀一ⴀ唀匀∀㸀 琀栀愀琀 爀攀氀椀愀戀氀攀 搀愀琀愀 漀渀 琀栀攀 椀洀洀甀渀攀 猀琀愀琀甀猀 漀昀 琀栀攀 瀀漀瀀甀氀愀琀椀漀渀 猀栀漀甀氀搀 戀攀 
routinely maintained. Financial support: CNPq, CAPES, FAPERJ, SR-2/UERJ</span><b style=""><span style="font-size: 10pt; font-family: &quot;Arial&quot;,&quot;sans-serif&quot;;" lang="EN-US"> <o:p></o:p></span></b></div>਀ 
਀ 
</font></p><br><b>Palavras-chave: </b>&nbsp;Diphtheria, Diphtheria antitoxin, Rio de Janeiro</td></tr></table></tr></td></table></body></html>਀�