Congresso Brasileiro de Microbiologia 2023

Congresso Brasileiro de Microbiologia 2023

Resumo: 1429-1

1429-1

DYNAMICS OF DENGUE VIRUS SEROTYPE CIRCULATION IN CENTRAL BRAZIL

Autores:

Ronaldo Rodrigues de Oliveira Junior (UFG - Universidade Federal de Goiás) ; Valéria Christina de Rezende Feres (UFG - Universidade Federal de Goiás) ; Caroline Pires Santana (UFG - Universidade Federal de Goiás) ; Christiane França Martins (UFG - Universidade Federal de Goiás) ; Isabella Ferreira da Costa (UFG - Universidade Federal de Goiás) ; Isabela Cinquini Junqueira (UFG - Universidade Federal de Goiás) ; Nayara Santos de Oliveira (SMS - GO - Secretaria Municipal de Saúde de Goiânia) ; Yves Mauro Fernandes Ternes (SMS - GO - Secretaria Municipal de Saúde de Goiânia)

Resumo:

The central region of Brazil has been experiencing a high incidence of dengue over the last 10 years. This study analyzed the circulation of dengue serotypes in Goiânia, Goiás, between 2015 and 2022. A dengue database was constructed using the Notifiable Diseases Information System (Sistema de Informação de Agravos de Notificação - SINAN). 1,102 records containing viral serotyping were selected and analyzed based on sociodemographic and clinical variables. The software R version 2022.12.0+353 was employed for data processing, database creation, and statistical analysis, using the Fisher exact test to evaluate the association between categorical variables and the outcome variable (serotype). The female gender exhibited a higher frequency of cases across all serotypes, ranging from 52.3% to 65.48%. For DENV-1, the age range affected was 10 to 59 years, while for DENV-2 and DENV-4, the highest frequencies were observed in the age groups of 20 to 29 years and 30 to 39 years, respectively. The mixed-race population and those with 13 years of education demonstrated the highest case frequencies. The most common symptoms were fever (41.9%), myalgia (41.30%), and headache (41.13%) (p < 0.05). Comorbidities and clinical signs of severity showed no relationship with the identified serotype. A replacement of the predominant serotype occurred in 2017 (DENV-1 to DENV-2) and in 2021 (DENV-2 to DENV-1). DENV-1 was identified in 53.5% of the records, DENV-2 in 38.3%, and DENV-4 in 8.2%. There was no difference in the percentage of deaths by serotype. These findings reveal the dynamics of circulation between DENV-1 and DENV-2 during the study period, the recurrence of DENV-1, and the complex interplay of inherent characteristics within the strain, host, and epidemiological context, collectively favoring the emergence of a new epidemic.

Palavras-chave:

Dengue virus, Epidemiology, Health database, Serotype

Agência de fomento:

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (Capes), Cons Nac de Desenv Científico e Tecnologia (CNPq), Faculdade de Farmácia (UFG), Secretaria Municipal de Saúde, Secretaria Estadual de Saúde, Instituto Aggeu Magalhães (FIOCRUZ-PE)