| Congresso Brasileiro de Microbiologia 2023 | Resumo: 975-1 | ||||
Resumo:The strengthening of copper-based metal alloys, with biocidal action when in solution, can help with issues potentially related to antimicrobial resistance in the environment. Antimicrobial metal alloys can be used as a coating for multiple surfaces and objects, including urban, clinical and industrial environments, such as elevator buttons, public transport seats and sanitary equipment. Biofilms are widely tolerated as important factors in the expression of multirresistant and nosocomial bacteria. Pseudomonas aeruginosa (ATCC 9721) is considered a model organism for evaluating microbial biofilms, since it is widely associated with health complications in immunocompromised patients. In addition, this bacterium is also related to high mortality rates in stricken patients by cystic fibrosis, neonatal complications, cancer and severe burns. The present study aimed the analysis of different compositions of copper-based metallic alloys of high entropy, evaluating their biocidal and inhibitory activity under biofilm formation by Pseudomonas aeruginosa. For this, a cell viability verification test was carried out, quantifying the conversion of resazurin reagent into resofurin, as a method to quantify the biofilm which was adhered into the copper alloys. All the analyses were carried out under four samples of high entropy metallic alloys, rich in copper, using two controls, pure copper alloy as positive control and pure steel as negative result. It was possible to select CuAlMnSn, indicating them as a potent material for recovery of surfaces, inhibiting the biofilm structuration and microbial contamination for different contexts. In order to understand the movements of acceleration of microbial growth and formation of biofilms, promoted by metallic alloys based on copper, it is intended to characterize the exhibitions through their microstructure, mechanical and magnetic properties, establishing a relationship between the different stable phases of the substrate and its properties (magnetic and thermal), correlating these data to their biocidal capacities. Palavras-chave: copper, metal alloys, high entropy alloys, microbicide materials Agência de fomento:CNPq MAI-DAI; CIM-EMBRAPII Unifesp, Termomecanica São Paulo S.A. | |||||