Congresso Brasileiro de Microbiologia 2023

Congresso Brasileiro de Microbiologia 2023

Resumo: 626-2

626-2

GRAM-NEGATIVE BACTERIA AS AGENTS OF VENTILATOR-ASSOCIATED PNEUMONIA (VAP) IN A TERTIARY HOSPITAL IN MINAS GERAIS: A RETROSPECTIVE EPIDEMIOLOGICAL STUDY

Autores:

Mariana Rodrigues Paiva (PPGENF/UFJF - PPg. ENFERMAGEM, UNIVERSIDADE FEDERAL DE JUZ DE FORA) ; Cristina Nantes Miranda (PPGENF/UFJF - PPg. ENFERMAGEM, UNIVERSIDADE FEDERAL DE JUZ DE FORA) ; Camila Quinetti Paes Pittella (DEP.EBA/UFJF - DEP. ENFERMAGEM BÁSICA, UNIVERSIDADE FEDERAL DE JUIZ DE FORA) ; Thiago Cesar Nascimento (PPGENF/UFJF - PPg. ENFERMAGEM, UNIVERSIDADE FEDERAL DE JUZ DE FORA, DEP.EBA/UFJF - DEP. ENFERMAGEM BÁSICA, UNIVERSIDADE FEDERAL DE JUIZ DE FORA)

Resumo:

Ventilator-associated pneumonia (VAP) occurs in patients who receive mechanical ventilation after aproximately 48 hours. The mortality associated with VAP ranges from 24 to 76%, being higher among the most severely patients. In Brazil the VAP is in the first place in healthcareassociated infections (HAIs), representing the overall rate of 13,0% in 2021 in adult’s intensive care units (ICUs). The most common microorganisms associated with VAP are Pseudomonas aeruginosa and Staphylococcus aureus, however, multiresistant gram negative species as Escherechia coli and Klebsiella pneumoniae have been representative mainly due to the use of empirical antibiotic therapy and late diagnosis of VAP. The purpose of this study was to evaluate the gram-negative pathogens responsible for VAP in patients admitted to the ICU of a tertiary hospital, between 2018 and 2022. It was conducted a retrospective analysis using hospital’s database, where data associated with VAP were selected. Among a total of 316 gram-negative pathogens islotated from patients hospitalized with VAP, the most frequent were Acinetobacter baumannii and Klebsiella pneumoniae (22.2%) followed by Pseudomonas aeruginosa (20,6%). The highest rates of resistance were observed against ampicillin/sulbactam (79.3%), imipenem (67.2%) and ceftazidime (62.2%). This study presented the occurrence of multidrug-resistant gram-negative bacteria associated with the occurrence of VAP in ICUs and reveals the need for discussion about the importance of preventive measures such as direct monitoring of patients using mechanical ventilation by infection control professionals, use of prevention protocols by the sector, training of healthcare professionals regarding hand hygiene, care planning by multidisciplinary teams, in addition to the rational use of antimicrobials.

Palavras-chave:

Ventilator-Associated Pneumonia, Gram-Negative Bacterial Infections, Epidemiology

Agęncia de fomento:

CNPq, CAPES, FAPEMIG, PPgENF/UFJF