| Congresso Brasileiro de Microbiologia 2023 | Resumo: 242-1 | ||||
Resumo:Hospital effluents are considered emerging contaminants in wastewater from sewage treatment plants and have generated increasing concern ins recent years. With the advancement in the production of new medicines, their greater distribution and application aiming at improving health is inevitable. However, it is important to note that pharmaceuticals are complex substances developed and used with the purpose of promoting specific biological effects and being easily excreted, either in their original form or as metabolites. When excreted, their destination is a treatment plant that uses the same methodology to treat urban effluents, making any decontamination of hospital effluents incidental and inherent to the treatment process. Generally, monitoring the quality of effluent generated in treatment plants is based on physicochemical parameters and the presence of coliforms, without considering more specific biological parameters. This study presents a comparative analysis among three treatment plants located in Barretos – SP, two of which receive the waste generated by the Cancer Hospital, one of the largest and most sophisticated oncological treatment centers in Latin America, with 120 beds and approximately four thousand medical appointments per day. In the years 2022 and 2023, samples were collected during the four seasons to understand the difference and similarities among three treatment plants, two of which receive the urban + hospital effluent: WWTP III and WWTP IV, in contrast to the plant that only receives the urban effluent: WWTP II. Three sampling points were selected in each plant, namely the raw sewage entry, the exit of the facultative pond (WWTP II and WWTP III), the exit of the aeration tank (WWTP IV), and the exit of the treated sewage. Physicochemical parameters such as pH, turbidity, conductivity, settleable solids, sulfate, sulfide, barium, BOD and COD were evaluated. The freeze-dried samples were also subjected to infrared spectroscopy and elemental analysis. Simultaneously, microbial resistance analysis was performed using following antibiotics: Streptomycin, Penicilin, Rifampicin, Sulfamethoxazole/Trimethoprim, Erythromycin, Teicopanin, Vancomycin, Ceftriaxone, Tobramycin, Oxacillin, Nitrofurantoin, Trimethoprim, Polymyxin B, and Ticarcillin/Clavulanic acid. The physicochemical parameters were subjected to multivariate analysis, followed by Duncan or Kruskal Wallis multiple comparison test, and barium was found in higher concentrations in WWTPs III and IV, with may indicate the release of contrast agents that use barium as a reagent and are applied to patients in healthcare centers. The microbiological analysis results indicate higher resistance in WWTPs III and IV, and greater sensitivity in WWTP II, suggesting that the waste generated by the hospital may be contributing to the spread of multidrug-resistant bacteria.
Development Agency: CAPES – Coordenação de Aperfeiçoamento de Pessoas de Nível Superior. Palavras-chave: Comparative investigation, Pharmaceutics impact, Sewage physical-chemical analyses Agência de fomento:Coordenação de Aperfeiçoamento de Pessoas de Nível Superior - CAPES | |||||