| Congresso Brasileiro de Microbiologia 2023 | Resumo: 148-1 | ||||
Resumo:Corynebacteria, commonly associated with commensal colonization of human skin and mucous membranes, have often been overlooked in the spectrum of urinary and genital tract infections. Recent advances in molecular and diagnostic techniques have unveiled their greater prevalence and diversity, leading to renewed interest in their role within the context of frank infections. Today we have a wealth of clinical and genomic data, as well as ample insights into host-pathogen interactions necessary to shed light on the intricate relationship between corynebacteria and the urinary/genital tract. The talk will emphasize instances where corynebacteria have been implicated as causative agents of infections, challenging the traditional view of their purely commensal role, as well as highlight the role of specific species (such as Corynebacterium urealyticum, Corynebacterium glucuronolyticum and Corynebacterium accolens). Furthermore, it will evaluate the impact of antibiotic resistance patterns among corynebacteria strains and their potential contribution to treatment challenges in the infections of urinary and/or genital tract. The importance of accurate identification and differentiation of corynebacteria strains to discern their true clinical relevance will be also highlighted. Such insights are critical in guiding effective diagnostic and therapeutic strategies tailored to individual patients, with the potential to mitigate the risks associated with overtreatment or undertreatment. Ultimately, the aim is to bridge the gap between the historically peripheral role of corynebacteria in urinary/genital tract infections and the evolving understanding of their potential pathogenicity. By deciphering the intricacies of this enigmatic relationship, there is a foundation for further research, improved clinical decision-making, and the development of targeted interventions to address infections involving these microorganisms. Palavras-chave: corynebacteria, genital infections, urinary tract infections, antibiotic resistance, molecular diagnosis Agęncia de fomento: | |||||